Lupine peptides & Apple Botopical wrinkle freeze cream

Introducing Anni Mateo’s Lupine Peptides & Apple Botopical Wrinkle Freeze Cream, a powerful formula designed to combat signs of aging effectively. With a potent blend of 20% Argireline (Acetyl hexapeptide-3), Lupine peptides, and Botopical®, this cream delivers a Botox-like active ingredient for a skin-relaxing effect.

In addition to these powerful ingredients, the cream boasts a range of other active components at high concentrations. Apple extracts, tomato, and red berries, along with vitamins A, B, C, D, and E, hyaluronic acid, MSM, hydrolyzed wheat proteins, hydrolyzed oats, and squalane provide intensive anti-aging and antioxidant properties.

The antioxidants in this cream detoxify and neutralize free radicals caused by air pollution, sunlight, alcohol, cigarette smoke, and stress. Lycopene from tomatoes protects the collagen of the skin, while the tonic effects of lycopene balance sebum in the skin.

Formulated with mostly food-grade, natural ingredients, this cream is free of petroleum products, parabens, silicones, fillers, synthetic fragrances, colors, and harsh preservatives. Suitable for all skin types, it is particularly effective for addressing expression wrinkles, dry, sensitive, and stressed skin, suitable for both day and night use.

This cream is formulated for all skin types but is particularly useful for expression wrinkles and dry, sensitive and stressed skin for night and day. If used as a day cream, please use additional sunscreen if out for prolonged periods in sunlight due to the low natural SPF in this cream. For men and women.

The active ingredients include a mix of peptides, vitamins, natural antioxidants from apple and berries and a plethora of high-tech ingredients

  • Contains 20% Argireline (Acetyl hexapeptide-3), Lupine peptides and Botopical.
  • Made with extracts of Apple, Tomato and red berries, full of antioxidants such as Lycopene and polyphenols, which softens and smoothens the skin to give it an ideal texture and fights free radical damage caused by air pollution, sunlight, alcohol, cigarette smoke and stress.
  • Packed with high concentrations of proven actives and potent anti-aging and wrinkle fighters & Collagen builders, such as hydrolyzed Lupine peptides, Botopical, vitamin A palmitate, vitamin C ester, hydrolyzed Wheat and Oats proteins, hyaluronic acid as well as MSM, niacinamide and pro-vitamin B5 for cell repair and renewal (which also promotes even skin tone and clears acne and inflamed skin).
  • Promotes 24 hours hydration due to hyaluronic acid, squalane, vegetable glycerine, argan oil and the unique combination of pure oils and butters.

What the active ingredients do

BOTOPICAL®, a BOTOX®-like cosmetic solution and a non-aggressive alternative to reduce expression wrinkles. Rich in organic compounds from rye, Botopical favours the relaxation of subcutaneous muscles, thus correcting wrinkles caused by facial movements.

They offer a long-lasting tensor effect by stimulating the mechanical cell functions involved in the modulation of skin tension forces and reducing the phenomena of micro tensing to visibly smooth expression lines. Botopical relaxes the features while at the same time conversing the natural mobility of the face.

Botopical stimulates the formation of mechano-receptors. Tested at 0.25 % on normal human fibroblasts, Botopical stimulates the synthesis of integrin α2 ß 1 by 20 % and boosts the synthesis of vinculin, a marker of focal adhesions, by 28%.

Botopical increases the mechanical resistance of the skin. Tested at 0.50% on normal human fibroblasts, Botopical led to a 62% increase in the synthesis of -SMA fibres, responsible for the retractile forces of fibroblasts. Moreover, the in vivo tests have shown the anti-wrinkle properties of Botopical at 4% after 56 days of treatment on the level of the crow’s foot and the nasolabial fold in 72% and 78% of volunteers, respectively.

ARGIRELINE (Acetyl hexapeptide-3): Argireline works through a unique mechanism which relaxes facial tension leading to a reduction in superficial facial lines and wrinkles with regular use. Argireline has been shown to moderate excessive catecholamines release. Anti-age hexapeptide developed with combinatorial chemistry and high throughput screening techniques.

It reduces the severity of wrinkles around the eyes, up to 17% after 15 days of treatment and up to 27% after 30 days of treatment. It reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes. It prevents skin aging induced by repeated facial movements caused by excessive catecholamine release.

Argireline can be incorporated in cosmetic formulations such as emulsions, gels, serums, etc., where removing deep lines or wrinkles in the forehead or around the eye area is desired. The recommended use level is 3-10% of the solution to obtain significant anti-wrinkle activity. Popular Botox-alternative wrinkle treatments on the market use as much as 15% Argireline. However, this cream contains 20%.

LUPINE PEPTIDES: Lupine peptides is a blend of Penta- and Hexa- peptides derived from lupin flower protein that works as an MMP inhibitor, thus preventing MMP activity following exposure of the skin to sunlight. By doing this, the lupine peptides blend prevents collagen and elastin (the main proteins making up connective tissue) breakdown catalysed by MMP activity, helping to renew the skin’s outer layer, reduce the depth of wrinkles and stimulating the production of collagen & elastin, giving the skin a younger look.

For my current listings on eBay and Etsy, please see ActiveCosmeticCreams – Etsy Ireland and Anni Mateo Anti-aging SkinCare | eBay Stores, respectively. 

Weight 99 g


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Lupine peptide & Apple Botopical wrinkle freeze cream 20% Argireline vitamins ABCDE

Anni Mateo Lupine peptides & Apple Botopical wrinkle freeze cream.


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